doi: Ena SL, De Backer J-F, Schiffmann SN, de Kerchove d’Exaerde A (2013) FACS array profiling identifies Ecto-5′ nucleotidase as a striatopallidal neuron-specific Gene involved in striatal-dependent learning. Neuropsychopharmacology 41:1003–1013. Proc Natl Acad Sci U S A 109:6265–6270. Sleeping is really important and now I understand why I need to drink coffee to keep me awake. doi: Obeso JA et al (2000) Pathophysiologic basis of surgery for Parkinson’s disease. doi: Qu W-M et al (2006) Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. USA.gov. Now I have some facts to back me up when I nag my granddaughter to get a good night's sleep! Temperature 2:406–417. Huitron-Resendiz S et al (2005) Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. Xiang L, Feng Y, Hu Q, Zhu J, Ye R, Yuan Z. Biomed Res Int. Elife 3:e02172. The cholinergic basal forebrain is reviewed in detail as an essential area for mediating the sleep-inducing effects of adenosine by inhibition of wake-promoting neurons via the A1 receptor. doi: Urade Y, Hayaishi O (2011) Prostaglandin D2 and sleep/wake regulation. Moreover, the popular demand for natural sleep aids has led to a search for natural compounds that can promote sleep via adenosine receptor activation. doi: Chait LD (1992) Factors influencing the subjective response to caffeine. Science. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. reverse transcription-polymerase chain reaction, https://doi.org/10.1016/j.pneurobio.2004.06.004. Therefore, scientists feel that adenosine is the way the body keeps track of how much sleep you've gotten, and how much sleep you need. Margaret Perrottet (author) from San Antonio, FL on September 11, 2012: @healthylife2 - You may want to boost your exercise level up to increase the adenosine, or take a melatonin supplement. doi: Byrne EM, Johnson J, McRae AF, Nyholt DR, Medland SE, Gehrman PR, Heath AC, Madden PA, Montgomery GW, Chenevix-Trench G, Martin NG (2012) A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. If they do, will they still have two types of sleep? Curr Top Med Chem. eCollection 2020. Arnaud MJ (2011) Pharmacokinetics and metabolism of natural methylxanthines in animal and man. This is a preview of subscription content, Adler CH, Thorpy MJ (2005) Sleep issues in Parkinson’s disease. Adenosine may act via A1 receptors to promote sleep, but an A2a receptor antagonist can block the sleep induced by prostaglandin D 2.We previously reported that prostaglandin D 2 activates sleep-promoting neurons of the ventrolateral … Nature 395:281–284. Wang Y-Q, Li R, Wang D-R, Cherasse Y, Zhang Z, Zhang M-Q, Lavielle O, McEown K, Schiffmann SN, Kerchove d’Exaerde A, Qu WM, Lazarus M, Huang Z-L. Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents.
Z Allegem Physiol 14:235–262. Don't need melatonin now..
Voted up, interesting and useful. Neurology 55:S7–12, Ochiishi T et al (1999a) Cellular localization of adenosine A1 receptors in rat forebrain: immunohistochemical analysis using adenosine A1 receptor-specific monoclonal antibody. Curr Opin Cell Biol 27:51–55. Mediators Inflamm. Adenosine signaling has profound effects on sleep, many of which depend on the adenosine A2A receptor (A2AR). Possible roles of central nervous system adenosine receptors. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/.
https://doi.org/10.1007/s41105-020-00260-2. Eur J Neurosci 31:499–507. Jenner P, Mori A, Hauser R, Morelli M, Fredholm BB, Chen JF (2009) Adenosine, adenosine A2A antagonists, and Parkinson’s disease. Voting this up, useful, and interesting :). doi: Fredholm BB (2007) Adenosine, an endogenous distress signal, modulates tissue damage and repair.
Nature 461:282–286. The A (2A)R plays a predominant role in the somnogenic effects of PGD (2). Copyright © 2020 Elsevier B.V. or its licensors or contributors. Sleep regulation in adenosine A2A receptor-deficient mice. While I am always hearing about how much sleep we need, I had not thought much about WHY we sleep. Sci Transl Med 7:146–305.
Curr Opin Neurobiol 23:780–785. doi: Burnstock G, Verkhratsky A (2012) Mechanisms of ATP release and inactivation. Satoh S, Matsumura H, Koike N, Tokunaga Y, Maeda T, Hayaishi O (1999) Region-dependent difference in the sleep-promoting potency of an adenosine A2A receptor agonist. Nat Neurosci 10:1131–1133. doi: Benington JH, Kodali SK, Heller HC (1995) Stimulation of A1 adenosine receptors mimics the electroencephalographic effects of sleep deprivation. Yamaguchi H, Maruyama T, Urade Y, Nagata S (2014) Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. The A2A receptor in the subarachnoid space below the rostral forebrain may play a role in the prostaglandin D2-mediated somnogenic effects of adenosine. Cite as. By use of gene-manipulated mice, the arousal effect of caffeine was shown to be dependent on the A(2A)R. On the other hand, inhibition of wake-promoting neurons via the A(1)R also mediates the sleep-inducing effects of adenosine, whereas activation of A(1)R in the lateral preoptic area induces wakefulness, suggesting that A(1)R regulates the sleep-wake cycle in a site-dependent manner. 2005. Margaret Perrottet (author) from San Antonio, FL on May 22, 2013: Nationette - Glad you found this interesting.
doi: Svenningsson P, Fourreau L, Bloch B, Fredholm BB, Gonon F, Le Moine C (1999) Opposite tonic modulation of dopamine and adenosine on c-fos gene expression in striatopallidal neurons. Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO.
Kris Heeter from Indiana on August 26, 2012: Very nice fact-filled hub!
Behav Pharmacol 2:345–356. Thanks so much for reading and voting - I greatly appreciate it! Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB (2007) EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Answer: Since the stage four (deep sleep) cycle is very important for the restoration of the brain and body, you certainly could be feeling some ill effects from missing out on this important cycle.
J Neurosci 28:2970–2975, Sherin JE, Shiromani PJ, McCarley RW, Saper CB (1996) Activation of ventrolateral preoptic neurons during sleep. Scientists are even concerned about the light emitted from our electronic devices such as smart phones, laptops, tablets and E-readers. doi: Fredholm BB, IJzerman AP, Jacobson KA, Linden J, Muller CE (2011) International Union of Basic and Clinical Pharmacology. Article 2014;119:349-71. doi: 10.1016/B978-0-12-801022-8.00014-3.
doi: Eltzschig HK (2009) Adenosine: an old drug newly discovered. Jack Baumann from St. Louis, Missouri on March 22, 2013: We sleep because its life little break from the hardship of the day!! Haha! doi: Müller CE, Jacobson KA (2011) Recent developments in adenosine receptor ligands and their potential as novel drugs. In addition, time spent in REMS during the light phase was increased. Urade Y, Eguchi N, Qu W-M, Sakata M, Huang Z-L, Chen J-F, Schwarzschild MA, Fink JS, Hayaishi O. doi: Atack JR et al (2014) JNJ-40255293, a novel adenosine A, Augusto E et al (2013) Ecto-5′-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A. Bachmann V et al (2012) Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Eur J Neurosci 40:3504–3511. CNS Neurol Disord Drug Targets 8:235–244. Margaret Perrottet (author) from San Antonio, FL on March 03, 2013: THEmikeLO - thanks so much for stopping by and taking the time to read and comment. Considerable evidence indicates that adenosine may be an endogenous somnogen, yet the mechanism through which it promotes sleep is unknown. Fields RD, Stevens B (2000) ATP: an extracellular signaling molecule between neurons and glia. Nutrients. Methippara MM, Kumar S, Alam MN, Szymusiak R, McGinty D. Am J Physiol Regul Integr Comp Physiol. Neuropsychopharmacology 30:891–900. | The role of adenosine in the regulation of sleep. Nakamura Y, Midorikawa T, Monoi N, Kimura E, Murata-Matsuno A, Sano T, Oka K, Sugafuji T, Uchiyama A, Murakoshi M, Sugiyama K, Nishino H, Urade Y (2016) Oral administration of Japanese sake yeast (Saccharomyces cerevisiae sake) promotes non-rapid eye movement sleep in mice via adenosine A2A receptors. doi: Dale N, Frenguelli BG (2012) Measurement of purine release with microelectrode biosensors. Ado production by the central nervous system is related to …
Kasman - perhaps you're working out too close to the time you're trying to sleep. Trends Neurosci 35:723–732. This is why Melatonin is often taken as a natural sleep aid, and is successful for many people. Scammell TE, Gerashchenko DY, Mochizuki T, McCarthy MT, Estabrooke IV, Sears CA, Saper CB, Urade Y, Hayaishi O. Neuroscience. Br J Pharmacol 165:1904–1913. Huang Z-L, Qu W-M, Eguchi N, Chen J-F, Schwarzschild MA, Fredholm BB, Urade Y, Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Hauser RA et al (2011) Preladenant in patients with Parkinson’s disease and motor fluctuations: a phase 2, double-blind, randomised trial. The A(2A)R plays a predominant role in the somnogenic effects of PGD(2). doi: Feldberg W, Sherwood SL (1954) Injections of drugs into the lateral ventricle of the cat. Adenosine has an essential function in many biochemical processes and is one of many neurotransmitters and neuromodulators affecting the complex behavior of sleep, particularly the initiation of sleep. : +1 508 583 4500x1879; fax: +1 508 586 0894. Clin Pharmacol Ther 81:692–698, Rivkees SA, Price SL, Zhou FC (1995) Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum, and basal ganglia. This structure receives light waves from the eye directly through the optic nerve. Margaret Perrottet (author) from San Antonio, FL on August 02, 2012: Thanks for taking the time to read, comment and vote, Stephanie. doi: Bodenmann S, Hohoff C, Freitag C, Deckert J, Rétey JV, Bachmann V, Landolt HP (2012) Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.
doi: Chen Y et al (2006) ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.
Neurology 61:S94–S96, Ushikubi F et al (1998) Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Proc Natl Acad Sci U S A 93:5980–5984. While total time spent in each stage of wakefulness, non-rapid eye movement sleep (NREMS), and rapid eye movement sleep (REMS) was normal in A2AR-KO mice, the episode durations of NREMS and REMS were reduced, suggesting that both stages are more fragmented. - 18.104.22.168. Am J Physiol Regul Integr Comp Physiol 289:R1715–R1723. 2020 May 15;21(1):408. doi: 10.1186/s13063-020-04299-x. Neurology 61:S19–S23, Gallopin T et al (2005) The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus.
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