cytidine monophosphate kinase

New York: Oxford Univ. the National Science Foundation (DBI-1832184), UMP-CMP kinase. 56: 562-569, 1999. J. Biol. Overall, CMP was the best substrate. [PubMed: 561097, related citations] ATP and dATP were the best phosphate donors, whereas CTP was the poorest. [PubMed: 36070, related citations] (from NCBI), Cook, P. J. L., Hamerton, J. L. These nucleoside diphosphates are required for cellular nucleic acid synthesis ( Liou et al., 2002 ). Uridine kinase catalyzes the addition of the first phosphate to uridine to form UMP, whereas UMPK catalyzes the addition of the second phosphate to form UDP. , UMP/CMP kinase Two of 3 UMPK2 homozygotes were children with prolonged respiratory infection.

Van Rompay et al. 25: 9-20, 1979. *191710 Cell Genet. Report of the committee on the genetic constitution of chromosome 1. CMP can be phosphorylated to cytidine diphosphate by the enzyme CMP kinase, with adenosine triphosphate or guanosine triphosphate donating the phosphate group. Such usage, however, is inaccurate, since the 2 enzymes catalyze different steps in nucleoside triphosphate synthesis. Bacterial cytidine monophosphate (CMP) kinases are characterised by an insert enlarging their CMP binding domain, and by their particular substrate specificity. An alternate strategy involves inhibition of UCK2 to block pyrimidine salvage in cancerous cells. , thymidylate kinase family LPS-inducible member 26: 627-635, 1974. [Full Text: https://dx.doi.org/10.1159/000131394], Gallango, M. L., Muller, A., Suinaga, R. Am. [PubMed: 207182, related citations], Giblett, E. R., Anderson, J. E., Chen, S.-H., Teng, Y.-S., Cohen, F. (1974) that the ability of immunocompetent lymphocytes to respond to appropriate stimuli is impaired in the UMPK2 homozygote in a manner similar to the immune defect resulting from adenosine deaminase deficiency. Human Polymorphic Genes: World Distribution. (2002) concluded that the shorter form is the endogenously translated protein. [PubMed: 207182], Giblett, E. R., Anderson, J. E., Chen, S.-H., Teng, Y.-S., Cohen, F. The polymorphism of the red cell uridine monophosphate kinase in two samples of the Italian population. 27: 332-335, 1977. Cytidine monophosphate kinase (CMPK), a member of the nucleoside monophosphate kinase family, plays an important role in the biosynthesis of nucleoside metabolism, DNA repair and tumour development. Thus, both CMP and 2'-deoxy-CMP (dCMP) are good phosphate acceptors for the CMP kinase from Escherichia coli (E. coli CMPK), whereas eukaryotic UMP/CMP kinases phosphorylate the deoxynucleotides with very low efficiency. A new polymorphic enzyme, uridine monophosphate kinase: gene frequencies and a linkage analysis. Uridine 5'-monophosphate (5'-UMP) and cytidine 5'-monophosphate (5'-CMP) were biosynthesized by recombinant uridine-cytidine kinase (UCK) and acetate kinase (ACK).

, dCMP kinase Other designations UMP-CMP kinase 2, mitochondrial, UMP/CMP kinase, cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial, cytidylate kinase 2, mitochondrial UMP-CMP kinase, nucleoside-diphosphate kinase, thymidine monophosphate kinase 2, thymidylate kinase family LPS-inducible member GeneRIFs: Gene References Into Functions Uridine monophosphate kinase polymorphism in two Venezuelan populations. Roychoudhury, A. K., Nei, M. This suggested to Giblett et al.

Ser. The interactive pathway map can be edited at WikiPathways: GRCh38: Ensembl release 89: ENSG00000143179, GRCm38: Ensembl release 89: ENSMUSG00000026558, "Entrez Gene: UCK2 uridine-cytidine kinase 2", "Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative", "Confocal imaging-guided laser ablation of basal cell carcinomas: an ex vivo study", "Structural and Biochemical Studies on the Reaction Mechanism of Uridine-Cytidine Kinase", "Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23", "Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification", "Sensitivity of Human Cancer Cells to the New Anticancer Ribo-nucleoside TAS–106 Is Correlated with Expression of Uridine-cytidine Kinase 2", "A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides", "In Silico Discovery of Potential Uridine-Cytidine Kinase 2 Inhibitors from the Rhizome of Alpinia mutica", "Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase", "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels", https://en.wikipedia.org/w/index.php?title=UCK2&oldid=984428220, Creative Commons Attribution-ShareAlike License, Overview of all the structural information available in the, This page was last edited on 20 October 2020, at 01:46. Studies determining the Michaelis-Menten kinetic parameters for these enzymes revealed that UCK2 had a four to sixfold higher binding affinity, faster maximal rates, and greater efficiencies for uridine and cytidine substrates than did UCK1.

(1999) characterized the enzymatic activity of recombinant UMP/CMP kinase. Cook, P. J. L., Hamerton, J. L. [§ 1], 1udw: Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, CTP, 1uei: Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, UTP, 1uej: Crystal structure of human uridine-cytidine kinase 2 complexed with a substrate, cytidine, 1ufq: Crystal structure of ligand-free human uridine-cytidine kinase 2, 1uj2: Crystal structure of human uridine-cytidine kinase 2 complexed with products, CMP and ADP, 1xrj: Rapid structure determination of human uridine-cytidine kinase 2 using a conventional laboratory X-ray source and a single samarium derivative. 15: 146-152, 1975. [7] While UCK1 is expressed ubiquitously in a variety of healthy tissues including the liver, skeletal muscle, and heart, UCK2 has only been detected in placental tissue.

Satlin, A., Kucherlapati, R. S., Ruddle, F. H. Cell Sci. 24 Cytidine Monophosphate (UMP-CMP) Kinase 2, Mitochondrial (CMPK2) Anticorps de 9 fabricants sont disponibles sur www.anticorps-enligne.fr.

[PubMed: 396131] Assignment of the gene for human uridine monophosphate kinase to chromosome 1 using somatic cell hybrid clone panels.

UMP-CMP kinase Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. By radiation hybrid analysis, Van Rompay et al.

, cytidine monophosphate (UMP-CMP) kinase 1, cytosolic Donations are an important

Uridine monophosphate-cytidine monophosphate phosphotransferase. (1974) found genetic polymorphism of UMPK by means of starch gel electrophoresis.

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